Description

3-Chloro-4-Fluoro-6-Indazolecarboxylic Acid Methyl Ester is a high-purity, multi-functional heterocyclic building block of significant importance in modern synthetic chemistry. Its core value lies in its versatile indazole scaffold, which is strategically functionalized with chloro, fluoro, and ester groups, making it a critical intermediate for constructing complex molecular architectures. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly kinase inhibitors and other biologically relevant small molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted therapeutics, especially protein kinase inhibitors for oncology and inflammatory diseases.
• Agrochemical Research: Used in developing new active ingredients for crop protection products, leveraging its halogenated indazole core.
• Chemical Biology Probe Development: Serves as a scaffold for creating molecular probes to study enzyme function and cellular pathways.
• Material Science Research: Investigated as a monomer or additive for creating specialty polymers with unique electronic or optical properties.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting drug discovery and development pipelines.
• Academic Research: Utilized in university and institutional labs for methodological studies in heterocyclic and medicinal chemistry.

Basic Information

Product Name	3-Chloro-4-Fluoro-6-Indazolecarboxylic Acid Methyl Ester
CAS No.	885521-38-0
Molecular Formula	C9H6ClFN2O2
Molecular Weight	228.61 g/mol
Synonyms	Methyl 3-chloro-4-fluoro-1H-indazole-6-carboxylate; 3-Chloro-4-fluoro-1H-indazole-6-carboxylic acid methyl ester; 6-Indazolecarboxylic acid, 3-chloro-4-fluoro-, methyl ester; 885521-38-0; 3-Chloro-4-fluoro-6-(methoxycarbonyl)-1H-indazole; Methyl 3-chloro-4-fluoroindazole-6-carboxylate
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-Fluoro-6-Indazolecarboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with complete batch data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.