Description

6-Fluoro-4-Methyl-3-(1H)Indazole Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its indazole core structure with strategically positioned fluorine and carboxylic acid functional groups. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and target binding affinity. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for the creation of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly kinase inhibitors and other small molecule therapeutics.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize the potency and pharmacokinetic properties of lead compounds.
• Process Chemistry Development: Serves as a critical starting material or intermediate in the scale-up and optimization of API manufacturing routes.
• Biochemical Tool Compound: May be utilized in the development of probes for studying biological pathways and target validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the global pharmaceutical market.

Basic Information

Product Name	6-Fluoro-4-Methyl-3-(1H)Indazole Carboxylic Acid
CAS No.	885521-12-0
Molecular Formula	C9H7FN2O2
Molecular Weight	194.16 g/mol
Synonyms	6-Fluoro-4-methyl-1H-indazole-3-carboxylic acid; 6-Fluoro-4-methylindazole-3-carboxylic acid; 3-Carboxy-6-fluoro-4-methylindazole; 885521-12-0; 6-Fluoro-4-methyl-3-indazolecarboxylic acid; 1H-Indazole-3-carboxylic acid, 6-fluoro-4-methyl-
EINECS	Contact for details

Quality Control

Our 6-Fluoro-4-Methyl-3-(1H)Indazole Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.