Description

4-Bromo-6-Methylcarboxylate-1H-Indazole-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate with a distinct bromo-substituted indazole carboxylic acid structure. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting kinase inhibition and other enzymatic pathways.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Agrochemical Development: Serves as a building block for creating novel herbicides, fungicides, and plant growth regulators.
• Chemical Biology Probes: Employed in the development of labeled compounds and probes for studying biological mechanisms and target engagement.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	4-Bromo-6-Methylcarboxylate-1H-Indazole-3-Carboxylic Acid
CAS No.	885518-33-2
Molecular Formula	C11H9BrN2O4
Molecular Weight	313.11 g/mol
Synonyms	4-Bromo-6-(methoxycarbonyl)-1H-indazole-3-carboxylic acid; 1H-Indazole-3-carboxylic acid, 4-bromo-6-(methoxycarbonyl)-; 4-Bromo-6-methoxycarbonyl-1H-indazole-3-carboxylic acid; Methyl 4-bromo-3-carboxy-1H-indazole-6-carboxylate; 4-Bromo-6-methyl 1H-indazole-3,6-dicarboxylate; 885518-33-2; 4-Bromo-6-methoxycarbonylindazole-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 4-Bromo-6-Methylcarboxylate-1H-Indazole-3-Carboxylic Acid adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full traceability are provided for every shipment. We operate under a quality system designed to meet the expectations of cGMP and ISO standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.