Description

1H-Indole-7-Carbonitrile, 2,3-Dihydro-1-(3-Hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-Trifluoroethoxy)Phenoxy]Ethyl]Amino]Propyl]- is a high-purity, advanced pharmaceutical intermediate characterized by its complex indole-based molecular architecture. This compound is critical for the research and development of novel therapeutic agents, particularly in the fields of oncology and central nervous system (CNS) disorders. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of targeted, small-molecule drugs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of proprietary drug candidates targeting specific biological pathways.
• Oncology Research: Used in the development of potential anti-cancer agents due to the indole scaffold's prevalence in kinase inhibitors and other targeted therapies.
• CNS Drug Discovery: Serves as a precursor for compounds being investigated for neurological and psychiatric conditions.
• Chemical Biology: Employed as a molecular probe to study enzyme function and receptor interactions in biochemical assays.
• Process Chemistry Development: Used for scaling up and optimizing synthetic routes for new chemical entities (NCEs) under GMP conditions.
• Custom Synthesis: Basis for the preparation of specialized analogs and derivatives for structure-activity relationship (SAR) studies.

Basic Information

Product Name	1H-Indole-7-Carbonitrile, 2,3-Dihydro-1-(3-Hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-Trifluoroethoxy)Phenoxy]Ethyl]Amino]Propyl]-
CAS No.	885340-13-6
Molecular Formula	C25H28F3N3O3
Molecular Weight	475.51 g/mol
Synonyms	5-[(2R)-2-({2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl}amino)propyl]-2,3-dihydro-1-(3-hydroxypropyl)-1H-indole-7-carbonitrile; (R)-5-[2-[[2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl]amino]propyl]-2,3-dihydro-1-(3-hydroxypropyl)-7-cyanoindole; UNII-9T3Y6F6F8U; 9T3Y6F6F8U; CAS 885340-13-6; 1H-Indole-7-carbonitrile, 2,3-dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up work. Quality is verified through comprehensive analytical techniques including HPLC, GC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each batch, documenting purity, identity, and impurity profiles. We support development under quality agreements and can align with ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The compound may be hygroscopic; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.