Description

3-(2,5-Dioxo-Pyrrolidin-3-Yl)-1H-Indole-6-Carboxylic Acid is a high-purity, heterocyclic carboxylic acid derivative featuring a maleimide-functionalized indole scaffold. This compound matters as a versatile and critical building block for the synthesis of complex molecules, particularly in advanced pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for creating targeted therapies and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon for the development of small-molecule drugs targeting various disease pathways.
• Bioconjugation & ADC Development: The maleimide group enables selective conjugation to thiol-containing biomolecules (e.g., antibodies, peptides) for applications in Antibody-Drug Conjugates (ADCs) and targeted drug delivery systems.
• Proteomics Research: Used in the design and synthesis of activity-based probes (ABPs) and affinity tags for studying enzyme function and protein profiling.
• Material Science: Serves as a functional monomer or cross-linker precursor for synthesizing specialty polymers with tailored thermal or photochemical properties.
• Chemical Biology Tool Development: Employed in creating inhibitors, fluorescent labels, and other molecular tools for cellular and biochemical assays.

Basic Information

Product Name	3-(2,5-Dioxo-Pyrrolidin-3-Yl)-1H-Indole-6-Carboxylic Acid
CAS No.	885320-57-0
Molecular Formula	C13H10N2O4
Molecular Weight	258.23 g/mol
Synonyms	3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-3-yl)-1H-indole-6-carboxylic acid; 6-Carboxy-3-(2,5-dioxo-3-pyrrolinyl)indole; 1H-Indole-6-carboxylic acid, 3-(2,5-dihydro-2,5-dioxo-3H-pyrrol-3-yl)-; 3-(2,5-Dioxopyrrolidin-3-yl)-1H-indole-6-carboxylic acid; Maleimide-indole-6-carboxylic acid derivative; CAS 885320-57-0
EINECS	Contact for details

Quality Control

Our 3-(2,5-Dioxo-Pyrrolidin-3-Yl)-1H-Indole-6-Carboxylic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and may be hygroscopic; therefore, it should be handled under inert atmosphere when appropriate and kept in a desiccated environment for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.