Description

[2-(5-Bromo-Thiophen-2-Yl)-Ethyl]-Carbamic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active molecules. This compound is critical for research and development in medicinal chemistry, offering a protected amine functionality and a versatile bromo-thiophene scaffold for further functionalization. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing novel therapeutic agents, particularly in areas requiring heterocyclic building blocks.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the multi-step synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders, inflammation, or oncology.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes to explore new chemical entities.
• Protecting Group Strategy: The tert-butyloxycarbonyl (Boc) protecting group allows for selective amine deprotection under mild acidic conditions, enabling complex synthetic routes.
• Cross-Coupling Reactions: The bromine substituent on the thiophene ring makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to create diverse biaryl structures.
• Chemical Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening in drug discovery programs.
• Agrochemical Research: Potential use as an intermediate in the development of new crop protection agents and pesticides.
• Material Science Precursor: Can be utilized in the synthesis of organic semiconductors or conductive polymers due to the thiophene moiety.

Basic Information

Product Name	[2-(5-Bromo-Thiophen-2-Yl)-Ethyl]-Carbamic Acid tert-Butyl Ester
CAS No.	885279-60-7
Molecular Formula	C11H16BrNO2S
Molecular Weight	306.22 g/mol
Synonyms	tert-Butyl N-[2-(5-bromothiophen-2-yl)ethyl]carbamate; 2-(5-Bromo-2-thienyl)ethylcarbamic Acid 1,1-Dimethylethyl Ester; Boc-5-Bromo-2-thiopheneethylamine; N-Boc-2-(5-Bromothiophen-2-yl)ethylamine; 5-Bromo-2-thiopheneethylamine, N-Boc-; (5-Bromo-thiophen-2-yl)-ethyl]-carbamic acid tert-butyl ester; N-(tert-Butoxycarbonyl)-2-(5-bromothiophen-2-yl)ethanamine
EINECS	Contact for details

Quality Control

Our [2-(5-Bromo-Thiophen-2-Yl)-Ethyl]-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.