Description

Methyl 5,6-Dichloro-1H-Indazole-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant importance in modern drug discovery and development. Its value lies in its role as a key synthetic building block for constructing complex heterocyclic molecules, particularly in the creation of kinase inhibitors and other biologically active compounds. This product is essential for research institutions, contract research organizations (CROs), and pharmaceutical companies engaged in the synthesis of novel therapeutic agents targeting a range of diseases.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potent kinase inhibitors and other small-molecule drug candidates.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with improved efficacy and selectivity.
• Biochemical Tool Compound Synthesis: Employed to create specialized probes and inhibitors for studying specific enzymatic pathways and cellular processes in academic and industrial research.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of active pharmaceutical ingredients (APIs) for clinical trials and commercial use.
• Heterocyclic Chemistry: Serves as a versatile scaffold for the development of novel indazole-based compounds with potential applications across various therapeutic areas.

Basic Information

Product Name	Methyl 5,6-Dichloro-1H-Indazole-3-Carboxylate
CAS No.	885278-48-8
Molecular Formula	C9H6Cl2N2O2
Molecular Weight	245.06 g/mol
Synonyms	5,6-Dichloro-1H-indazole-3-carboxylic acid methyl ester; Methyl 5,6-dichloroindazole-3-carboxylate; 1H-Indazole-3-carboxylic acid, 5,6-dichloro-, methyl ester; 885278-48-8; 5,6-Dichloro-1H-indazole-3-carboxylic acid methyl ester; 3-Carbomethoxy-5,6-dichloroindazole
EINECS	Contact for details

Quality Control

Our Methyl 5,6-Dichloro-1H-Indazole-3-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as determined by advanced analytical techniques including HPLC, GC, and NMR. We support compliance with ICH guidelines and can provide material suitable for use in cGMP environments upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.