Description

(3-Boc-Amino-Piperidin-1-Yl)-(1H-Indol-2-Yl)-Acetic Acid is a high-purity, advanced pharmaceutical intermediate featuring a piperidine-indole acetic acid scaffold protected by a Boc (tert-butoxycarbonyl) group. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel drug candidates. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing therapeutics targeting central nervous system (CNS) disorders, oncology, and other specialized areas.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex active pharmaceutical ingredients (APIs) and investigational new drugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Protease Inhibitor Development: The piperidine-indole core structure is valuable for creating inhibitors of various enzymes, including proteases.
• Peptidomimetic Synthesis: Serves as a constrained amino acid analog for constructing peptide-like molecules with enhanced metabolic stability.
• Ligand Synthesis for GPCRs: Employed in the development of ligands targeting G-protein-coupled receptors (GPCRs), which are prevalent drug targets.
• Chemical Biology Probes: Used to create tool compounds for studying biological pathways and target validation.

Basic Information

Product Name	(3-Boc-Amino-Piperidin-1-Yl)-(1H-Indol-2-Yl)-Acetic Acid
CAS No.	885276-55-1
Molecular Formula	C20H27N3O4
Molecular Weight	373.45 g/mol
Synonyms	1-(1,1-Dimethylethyl) 2-[(3-[[(1,1-Dimethylethoxy)carbonyl]amino]-1-piperidinyl](1H-indol-2-yl)acetate; 2-[(3-[(tert-Butoxycarbonyl)amino]piperidin-1-yl](1H-indol-2-yl)acetic acid; (3-((tert-Butoxycarbonyl)amino)piperidin-1-yl)(1H-indol-2-yl)acetic acid; 2-[(3-Boc-aminopiperidin-1-yl)(1H-indol-2-yl)]acetic acid; Boc-Pip(3-NH2)-Indol-Acetic Acid; (3-Boc-Amino-1-piperidyl)-(1H-indol-2-yl)-acetic acid; N-Boc-3-amino-1-(1H-indol-2-yl-carbonylmethyl)piperidine
EINECS	Contact for details

Quality Control

Our (3-Boc-Amino-Piperidin-1-Yl)-(1H-Indol-2-Yl)-Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥97.0%
Purity (HPLC, Area %)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.