Description

(3-Boc-Amino-Azetidin-1-Yl)-Thiophen-2-Yl-Acetic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique molecular scaffold combining an azetidine ring with a thiophene moiety. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting a range of therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in drug discovery programs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its versatile azetidine-thiophene core for molecular diversification.
• Protease Inhibitor Development: Serves as a precursor in the design and synthesis of potential protease inhibitors, given the structural motifs present.
• Custom Synthesis & Scale-Up: A starting material for contract manufacturing organizations (CMOs) performing custom synthesis and process development for clinical trial material.
• Bioconjugation & Probe Synthesis: The carboxylic acid and protected amine functionalities allow for conjugation to biomolecules or solid supports for chemical biology applications.
• Academic & Institutional Research: Employed in university and institutional labs for fundamental research in heterocyclic chemistry and new synthetic methodology development.

Basic Information

Product Name	(3-Boc-Amino-Azetidin-1-Yl)-Thiophen-2-Yl-Acetic Acid
CAS No.	885275-99-0
Molecular Formula	C14H20N2O4S
Molecular Weight	312.38 g/mol
Synonyms	2-[(3-{[(Tert-Butoxy)Carbonyl]Amino}Azetidin-1-Yl)(Thiophen-2-Yl)]Acetic Acid; 1-(Carboxymethyl)-3-[(Tert-Butoxycarbonyl)Amino]Azetidine-1-Thiophene-2-Acetic Acid; 3-(Boc-Amino)-1-(2-Carboxy-2-Thienyl)Azetidine; (3-Boc-Amino-1-Azetidinyl)(2-Thienyl)Acetic Acid; tert-Butyl N-[1-[(Carboxymethyl)(Thiophen-2-Yl)Methyl]Azetidin-3-Yl]Carbamate; Boc-Azetidine-Thiophene-Acetic Acid Intermediate; Azetidine-Thiophene Carboxylic Acid Derivative
EINECS	Contact for details

Quality Control

Our (3-Boc-Amino-Azetidin-1-Yl)-Thiophen-2-Yl-Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request. We support compliance with relevant guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.