Description

1-Boc-4-[Carboxy-(1H-Indol-2-Yl)-Methyl]-[1,4]Diazepane is a high-purity, advanced pharmaceutical intermediate featuring a protected diazepane scaffold linked to an indole carboxylic acid moiety. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel bioactive molecules targeting central nervous system (CNS) disorders and other therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of new drug candidates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those with potential neurological activity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel therapeutic agents.
• Protease Inhibitor Development: Serves as a core scaffold for designing inhibitors targeting specific enzymes.
• Peptidomimetic Synthesis: Employed in the creation of peptide-like compounds with enhanced stability and bioavailability.
• Chemical Biology Probes: Utilized to develop tool compounds for studying biological pathways and target validation.
• Custom Synthesis Projects: A starting material for contract manufacturing organizations (CMOs) producing bespoke APIs and advanced intermediates.

Basic Information

Item	Details
Product Name	1-Boc-4-[Carboxy-(1H-Indol-2-Yl)-Methyl]-[1,4]Diazepane
CAS No.	885275-76-3
Molecular Formula	C21H27N3O4
Molecular Weight	385.46 g/mol
Synonyms	1-Boc-4-[(1H-Indol-2-yl)(carboxy)methyl]-1,4-diazepane; tert-Butyl 4-[(1H-indol-2-yl)(carboxy)methyl]-1,4-diazepane-1-carboxylate; 1,4-Diazepane-1-carboxylic acid, 4-[(1H-indol-2-yl)carbonyl]-, 1,1-dimethylethyl ester; 885275-76-3; BOC-Protected Indole Diazepane Carboxylic Acid; (1H-Indol-2-yl)-BOC-diazepane carboxylic acid derivative.
EINECS	Contact for details

Quality Control

Our 1-Boc-4-[Carboxy-(1H-Indol-2-Yl)-Methyl]-[1,4]Diazepane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide comprehensive Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.