Description

5-Fluoro-2-Piperidin-2-Yl-1H-Benzoimidazole is a high-purity, advanced pharmaceutical intermediate belonging to the benzimidazole class of heterocyclic compounds. This compound is of significant commercial interest for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in drug discovery and process development for oncology, antiviral, and central nervous system (CNS) applications.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates targeting various disease pathways.
• Drug Discovery Research: Serves as a core scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Protease Inhibitor Development: Used in the research and development of inhibitors for specific enzymatic targets.
• Kinase Inhibitor Synthesis: An important building block for creating potential kinase inhibitors used in oncology research.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological processes and target validation.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for potential APIs.

Basic Information

Product Name	5-Fluoro-2-Piperidin-2-Yl-1H-Benzoimidazole
CAS No.	885275-05-8
Molecular Formula	C₁₂H₁₄FN₃
Molecular Weight	219.26 g/mol
Synonyms	5-Fluoro-2-(2-piperidinyl)-1H-benzimidazole; 2-(5-Fluoro-1H-benzimidazol-2-yl)piperidine; 1H-Benzimidazole, 5-fluoro-2-(2-piperidinyl)-; 5-Fluoro-2-piperidin-2-yl-1H-benzo[d]imidazole; 885275-05-8; 5-Fluoro-2-(piperidin-2-yl)-1H-benzoimidazole; 5-Fluoro-2-(2-piperidyl)-1H-benzimidazole
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-Piperidin-2-Yl-1H-Benzoimidazole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, to meet the stringent requirements of pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product is moisture-sensitive (hygroscopic); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.