Description

3-Aminomethyl-2-Cbz-1,2,3,4-Tetrahydro-Isoquinoline is a specialized, high-purity chemical building block of significant interest in advanced organic synthesis. This compound matters for its role as a key chiral intermediate in the development of complex, biologically active molecules, enabling precise structural modifications. It is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of novel drug candidates, particularly within medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral scaffold in the synthesis of potential therapeutic agents, including central nervous system (CNS) active compounds.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel drug discovery programs.
• Process Chemistry Development: Employed in route scouting and scale-up studies for the efficient production of active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Utilized as a building block for constructing complex molecules with defined stereochemistry.
• Chemical Biology Probes: Can be incorporated into molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects requiring specific tetrahydroisoquinoline frameworks.

Basic Information

Product Name	3-Aminomethyl-2-Cbz-1,2,3,4-Tetrahydro-Isoquinoline
CAS No.	885273-87-0
Molecular Formula	C18H20N2O2
Molecular Weight	296.37 g/mol
Synonyms	2-[(Benzyloxy)carbonyl]-1,2,3,4-tetrahydro-3-(aminomethyl)isoquinoline; 3-(Aminomethyl)-2-[(phenylmethoxy)carbonyl]-1,2,3,4-tetrahydroisoquinoline; 3-Aminomethyl-2-Cbz-THIQ; 2-Cbz-3-aminomethyl-1,2,3,4-tetrahydroisoquinoline; N-Cbz-3-aminomethyl-1,2,3,4-tetrahydroisoquinoline; 3-AMINO-METHYL-2-CBZ-1,2,3,4-TETRAHYDRO-ISOQUINOLINE; 3-(Aminomethyl)-2-(((benzyloxy)carbonyl)amino)-1,2,3,4-tetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our 3-Aminomethyl-2-Cbz-1,2,3,4-Tetrahydro-Isoquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.