Description

(1,2,3,4-Tetrahydro-Isoquinolin-3-Ylmethyl)-Carbamic Acid tert-Butyl Ester is a protected amine derivative of the tetrahydroisoquinoline scaffold, a privileged structure in medicinal chemistry. This compound serves as a critical advanced pharmaceutical intermediate (API intermediate) for the synthesis of complex bioactive molecules. It is primarily utilized by pharmaceutical R&D organizations and fine chemical manufacturers engaged in developing new therapeutic agents, particularly within the central nervous system (CNS) and oncology research fields.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for compounds containing the tetrahydroisoquinoline core.
• Alkaloid Synthesis: Serves as a precursor in the semi-synthesis or total synthesis of complex natural products and alkaloid analogs.
• Protease Inhibitor Development: Potential intermediate for the development of inhibitors targeting specific enzymatic processes.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying biological mechanisms and target identification.
• Scale-up Process Development: Employed in pilot and commercial-scale manufacturing processes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(1,2,3,4-Tetrahydro-Isoquinolin-3-Ylmethyl)-Carbamic Acid tert-Butyl Ester
CAS No.	885273-85-8
Molecular Formula	C16H22N2O2
Molecular Weight	274.36 g/mol
Synonyms	tert-Butyl N-[(1,2,3,4-tetrahydroisoquinolin-3-yl)methyl]carbamate; BOC-3-TIQ-CH2-NH2; N-Boc-3-(aminomethyl)-1,2,3,4-tetrahydroisoquinoline; 3-(Aminomethyl)-1,2,3,4-tetrahydroisoquinoline, N-Boc-protected; tert-Butyl (1,2,3,4-tetrahydro-3-isoquinolinylmethyl)carbamate; Carbamic acid, N-[(1,2,3,4-tetrahydro-3-isoquinolinyl)methyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our (1,2,3,4-Tetrahydro-Isoquinolin-3-Ylmethyl)-Carbamic Acid tert-Butyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The product is stable under these conditions. Keep away from strong acids and incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.