Description

(1,2,3,4-Tetrahydro-Isoquinolin-6-Yl)-Carbamic Acid tert-Butyl Ester is a high-purity, protected amine derivative used as a critical building block in advanced organic synthesis. This compound matters for its role as a versatile synthetic intermediate, enabling the construction of complex molecular architectures with high precision and yield. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing new active pharmaceutical ingredients (APIs), particularly within therapeutic areas targeting the central nervous system.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those with isoquinoline or tetrahydroisoquinoline scaffolds.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new pharmacophores.
• Peptidomimetic Synthesis: Serves as a protected amino component for constructing peptide-like molecules and enzyme inhibitors.
• Chemical Biology Probes: Utilized in the development of labeled compounds and molecular probes for biological target identification.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring high-purity, specialized intermediates.
• Academic & Institutional Research: Employed in university and institutional labs for methodological development in heterocyclic chemistry.

Basic Information

Product Name	(1,2,3,4-Tetrahydro-Isoquinolin-6-Yl)-Carbamic Acid tert-Butyl Ester
CAS No.	885273-75-6
Molecular Formula	C14H20N2O2
Molecular Weight	248.32 g/mol
Synonyms	tert-Butyl N-(1,2,3,4-tetrahydro-6-isoquinolinyl)carbamate; 6-[(tert-Butoxycarbonyl)amino]-1,2,3,4-tetrahydroisoquinoline; Boc-6-Amino-1,2,3,4-tetrahydroisoquinoline; N-Boc-1,2,3,4-tetrahydroisoquinolin-6-amine; N-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydro-6-isoquinolinamine; 6-(Boc-amino)-1,2,3,4-tetrahydroisoquinoline; BOC-THIQ-6-NH2
EINECS	Contact for details

Quality Control

Our (1,2,3,4-Tetrahydro-Isoquinolin-6-Yl)-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.