Description

5-(Tetrahydro-Pyran-4-Yl)-1H-Indole is a high-purity, advanced pharmaceutical intermediate characterized by its indole core fused with a tetrahydropyran moiety. This compound is of significant value for medicinal chemistry research and development, serving as a versatile building block for constructing complex molecular architectures. It is primarily sought after by R&D teams and process chemists in the pharmaceutical and biotechnology sectors for the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its privileged indole scaffold.
• API Development: Serves as a critical precursor in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs).
• Chemical Biology Probes: Employed in the development of molecular probes for studying biological pathways and target validation.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) offering bespoke chemical synthesis services.
• Academic Research: Utilized in university and institutional labs for exploratory organic synthesis and methodological development.

Basic Information

Product Name	5-(Tetrahydro-Pyran-4-Yl)-1H-Indole
CAS No.	885273-27-8
Molecular Formula	C13H15NO
Molecular Weight	201.27 g/mol
Synonyms	5-(Oxan-4-yl)-1H-indole; 5-(Tetrahydropyran-4-yl)-1H-indole; 5-(Tetrahydro-2H-pyran-4-yl)-1H-indole; 5-(4-Tetrahydropyranyl)indole; 1H-Indole, 5-(tetrahydro-4-pyranyl)-; 5-(THP-4-yl)-1H-indole; 5-(4-Pyranyl)indole, tetrahydro-
EINECS	Contact for details

Quality Control

Our 5-(Tetrahydro-Pyran-4-Yl)-1H-Indole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product should be kept under an inert atmosphere for long-term storage to maintain stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.