Description

5-(5-Methyl-Thiophen-2-Yl)-1H-Indazole is a high-purity, advanced pharmaceutical intermediate featuring a unique indazole-thiophene hybrid scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel small-molecule drug candidates targeting various therapeutic areas. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) around the indazole core.
• Chemical Biology Probes: Serves as a scaffold for developing molecular probes to study biological pathways and protein functions.
• Process Chemistry Development: Employed in route scouting and scale-up studies for the commercial manufacturing of active pharmaceutical ingredients (APIs).
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global drug discovery pipelines.
• Academic Research: Used in university and institutional labs for fundamental research in heterocyclic chemistry and drug discovery methodologies.

Basic Information

Product Name	5-(5-Methyl-Thiophen-2-Yl)-1H-Indazole
CAS No.	885272-88-8
Molecular Formula	C₁₂H₁₀N₂S
Molecular Weight	214.29 g/mol
Synonyms	5-(5-Methyl-2-thienyl)-1H-indazole; 1H-Indazole, 5-(5-methyl-2-thienyl)-; 5-(5-Methylthiophen-2-yl)-1H-indazole; 5-(5-Methyl-2-thienyl)indazole; 5-(5-Methylthien-2-yl)indazole; 885272-88-8; AKOS005258156
EINECS	Contact for details

Quality Control

Our 5-(5-Methyl-Thiophen-2-Yl)-1H-Indazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, supporting your regulatory and quality documentation needs for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a controlled, low-humidity environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.