Description

5-(Tetrahydro-Pyran-4-Yl)-1H-Indazole is a high-purity, advanced pharmaceutical intermediate with a unique heterocyclic scaffold. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for novel active pharmaceutical ingredients (APIs). It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of innovative therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Kinase Inhibitor Development: The indazole-pyran structure makes it a valuable fragment for developing potential kinase inhibitors for oncology and inflammatory diseases.
• Custom Synthesis Building Block: Employed in contract manufacturing and custom synthesis of complex molecules for clinical trials.
• Chemical Biology Probes: Utilized in the development of chemical probes to study biological processes and identify new drug targets.

Basic Information

Product Name	5-(Tetrahydro-Pyran-4-Yl)-1H-Indazole
CAS No.	885272-70-8
Molecular Formula	C₁₂H₁₄N₂O
Molecular Weight	202.25 g/mol
Synonyms	5-(Oxan-4-yl)-1H-indazole; 5-(Tetrahydropyran-4-yl)-1H-indazole; 5-(Tetrahydro-2H-pyran-4-yl)-1H-indazole; 5-(4-Tetrahydropyranyl)-1H-indazole; 1H-Indazole, 5-(tetrahydro-4-pyranyl)-; 885272-70-8; 5-(THP-4-yl)-1H-indazole
EINECS	Contact for details

Quality Control

Our 5-(Tetrahydro-Pyran-4-Yl)-1H-Indazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory filings for preclinical and clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). The material should be kept under an inert atmosphere if long-term stability is required.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.