Description

8-Chloro-1,3,4,4A,5,9B-Hexahydro-Pyrido[4,3-B]Indole-2-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic indole structure. This compound is of critical importance for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and neurological research. It is primarily needed by pharmaceutical R&D departments, contract research and manufacturing organizations (CROs/CMOs), and academic research institutions focused on developing next-generation therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of complex drug candidates targeting neurological disorders.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of new chemical entities.
• API Development: Integral in the process development and scale-up of novel Active Pharmaceutical Ingredients, especially in the psychotropic and neuropharmacology domains.
• Contract Manufacturing: Supplied to CMOs for the cGMP production of clinical trial materials and commercial APIs.
• Academic & Biotech R&D: Employed in university and biotech laboratories for exploratory research into new therapeutic pathways.
• Reference Standard: Can be utilized as a high-purity analytical standard for method development and quality control in API manufacturing.

Basic Information

Product Name	8-Chloro-1,3,4,4A,5,9B-Hexahydro-Pyrido[4,3-B]Indole-2-Carboxylic Acid tert-Butyl Ester
CAS No.	885272-52-6
Molecular Formula	C16H21ClN2O2
Molecular Weight	308.80 g/mol
Synonyms	tert-Butyl 8-chloro-1,3,4,4a,5,9b-hexahydro-2H-pyrido[4,3-b]indole-2-carboxylate; 8-Chloro-2-(tert-butoxycarbonyl)-1,3,4,4a,5,9b-hexahydro-2H-pyrido[4,3-b]indole; 8-Chloro-1,3,4,4a,5,9b-hexahydro-2H-pyrido[4,3-b]indole-2-carboxylic acid 1,1-dimethylethyl ester; 885272-52-6; Pyrido[4,3-b]indole derivative; BOC-protected pyridoindole intermediate.
EINECS	Contact for details

Quality Control

Our 8-Chloro-1,3,4,4A,5,9B-Hexahydro-Pyrido[4,3-B]Indole-2-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical R&D and cGMP manufacturing. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; therefore, the container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.