Description

8-Chloro-1,3,4,4A,5,9B-Hexahydro-Pyrido[4,3-B]Indole-2-Carboxylic Acid Ethyl Ester is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound matters as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders. It is primarily needed by R&D laboratories and production facilities in the pharmaceutical and biotechnology sectors for process development and scale-up manufacturing.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly for neurological and psychiatric applications.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic agents.
• Process Chemistry Development: Serves as a critical starting material or intermediate in the development and scaling of synthetic routes for APIs.
• Reference Standard: Employed as an analytical standard for quality control and method validation in pharmaceutical analysis.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Academic Research: Utilized in university and institutional labs for studying heterocyclic chemistry and developing new synthetic methodologies.

Basic Information

Product Name	8-Chloro-1,3,4,4A,5,9B-Hexahydro-Pyrido[4,3-B]Indole-2-Carboxylic Acid Ethyl Ester
CAS No.	885272-49-1
Molecular Formula	C15H17ClN2O2
Molecular Weight	292.76 g/mol
Synonyms	Ethyl 8-chloro-1,3,4,4a,5,9b-hexahydro-2H-pyrido[4,3-b]indole-2-carboxylate; 8-Chloro-2-ethoxycarbonyl-1,3,4,4a,5,9b-hexahydro-2H-pyrido[4,3-b]indole; 8-Chloro-1,3,4,4a,5,9b-hexahydro-2H-pyrido[4,3-b]indole-2-carboxylic acid ethyl ester; Pyrido[4,3-b]indole-2-carboxylic acid, 8-chloro-1,3,4,4a,5,9b-hexahydro-, ethyl ester; 885272-49-1; Ethyl 8-chloro-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole-2-carboxylate (alternative numbering).
EINECS	Contact for details

Quality Control

Our 8-Chloro-1,3,4,4A,5,9B-Hexahydro-Pyrido[4,3-B]Indole-2-Carboxylic Acid Ethyl Ester is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full traceability are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.