Description

4-Bromo-2,3-Dihydro-Indole-1-Carboxylic Acid tert-Butyl Ester is a high-purity, protected indole derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its value lies in the strategic positioning of the bromine atom and the acid-labile tert-butyl ester protecting group, enabling precise, multi-step synthesis of complex molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for constructing novel indole-based scaffolds for drug discovery and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that leverage the indole core structure.
• Material Science Research: Serves as a precursor for creating specialized organic compounds used in organic light-emitting diodes (OLEDs) and other advanced materials.
• Academic & Contract Research: A valuable reagent for method development and exploring new palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig amination).
• Peptidomimetics & Bioactive Molecule Design: The protected indole scaffold is utilized to mimic peptide structures and create molecules with enhanced biological activity and stability.

Basic Information

Product Name	4-Bromo-2,3-Dihydro-Indole-1-Carboxylic Acid tert-Butyl Ester
CAS No.	885272-46-8
Molecular Formula	C13H16BrNO2
Molecular Weight	298.18 g/mol
Synonyms	1-Boc-4-bromo-2,3-dihydroindole; 4-Bromo-2,3-dihydro-1H-indole-1-carboxylic acid, 1,1-dimethylethyl ester; tert-Butyl 4-bromo-2,3-dihydro-1H-indole-1-carboxylate; 4-Bromoindoline-1-carboxylic acid tert-butyl ester; N-Boc-4-bromoindoline; Boc-4-bromoindoline; 4-Bromo-N-Boc-indoline; 885272-46-8
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-2,3-Dihydro-Indole-1-Carboxylic Acid tert-Butyl Ester is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure compliance with exacting purity standards suitable for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect this light-sensitive compound from degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥97.0% (Area %)
Melting Point	Contact for details
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.