Description

7-Amino-2,3-Dihydro-Indole-1-Carboxylic Acid tert-Butyl Ester is a high-value, protected indole derivative that serves as a critical building block in modern synthetic organic chemistry. Its primary commercial value lies in its role as a versatile and reactive intermediate for constructing complex nitrogen-containing heterocycles, which are central to numerous active pharmaceutical ingredients (APIs). This compound is essential for research and development chemists and process scale-up teams in the pharmaceutical, agrochemical, and advanced materials sectors seeking to develop new therapeutic agents and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides that require specific indole-based scaffolds.
• Chemical Research & Development: Serves as a versatile starting material for constructing complex polycyclic structures in academic and industrial R&D laboratories.
• Peptidomimetics & Bioactive Molecule Design: The protected amino and carboxylic acid groups make it ideal for creating peptide analogs and other bioactive compounds.
• Material Science Precursor: Potential use in the synthesis of organic semiconductors, ligands for catalysis, and specialty polymers.

Basic Information

Item	Details
Product Name	7-Amino-2,3-Dihydro-Indole-1-Carboxylic Acid tert-Butyl Ester
CAS No.	885272-44-6
Molecular Formula	C₁₃H₁₈N₂O₂
Molecular Weight	234.29 g/mol
Synonyms	1H-Indole-1-carboxylic acid, 7-amino-2,3-dihydro-, 1,1-dimethylethyl ester; tert-Butyl 7-amino-2,3-dihydro-1H-indole-1-carboxylate; 7-Aminoindoline-1-carboxylic acid tert-butyl ester; Boc-7-aminoindoline; 7-Amino-2,3-dihydroindole-1-Boc; 885272-44-6; tert-Butyl 7-aminoindoline-1-carboxylate
EINECS	Contact for details

Quality Control

Our production of 7-Amino-2,3-Dihydro-Indole-1-Carboxylic Acid tert-Butyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for advanced synthetic applications. Each lot is subjected to comprehensive analytical testing, including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment. We support compliance with cGMP and ISO standards for pharmaceutical intermediate manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.