Description

tert-Butyl 2,6-Diazaspiro[3.5]Nonane-6-Carboxylate is a high-value, protected spirocyclic diamine building block used in advanced organic synthesis. This compound is essential for medicinal chemistry research and development, providing a rigid, three-dimensional scaffold that is crucial for modulating the biological activity and pharmacokinetic properties of new drug candidates. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents, particularly in central nervous system (CNS) and oncology drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of bioactive molecules and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Scaffold: Used to introduce a constrained, spirocyclic diamine moiety into candidate compounds to improve potency, selectivity, and metabolic stability.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker component connecting E3 ligase ligands to target protein binders.
• CNS Drug Discovery: Incorporated into molecules targeting neurological disorders due to the favorable physicochemical properties imparted by the spirocyclic structure.
• Chemical Biology Probe Synthesis: Used to create tool compounds for studying enzyme function and protein-protein interactions.
• Peptidomimetic Research: Acts as a non-natural amino acid surrogate to create more stable and bioavailable peptide analogs.

Basic Information

Product Name	tert-Butyl 2,6-Diazaspiro[3.5]Nonane-6-Carboxylate
CAS No.	885272-17-3
Molecular Formula	C12H22N2O2
Molecular Weight	226.32 g/mol
Synonyms	6-Boc-2,6-diazaspiro[3.5]nonane; 2,6-Diazaspiro[3.5]nonane-6-carboxylic acid, 1,1-dimethylethyl ester; tert-Butyl 2,6-diazaspiro[3.5]nonane-6-carboxylate; 6-(tert-Butoxycarbonyl)-2,6-diazaspiro[3.5]nonane; Boc-2,6-diazaspiro[3.5]nonane; 2,6-Diazaspiro[3.5]nonane, 6-Boc-protected; 885272-17-3; 6-N-Boc-2,6-diazaspiro[3.5]nonane
EINECS	Contact for details

Quality Control

Our tert-Butyl 2,6-Diazaspiro[3.5]Nonane-6-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.