Description

tert-Butyl 5-Amino-1H-benzo[de]isoquinoline-2(3H)-carboxylate is a high-purity, protected amine derivative of the benzo[de]isoquinoline heterocyclic system. This compound serves as a critical pharmaceutical intermediate and versatile building block for advanced organic synthesis. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the construction of complex molecules, particularly in drug discovery programs targeting various therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates, especially those containing fused polycyclic structures.
• Organic Synthesis Building Block: Used in amide coupling reactions, peptide mimetics, and as a protected amine for further functionalization in multi-step synthetic routes.
• Agrochemical Research: Serves as a scaffold for developing new herbicides, fungicides, and insecticides with potential novel modes of action.
• Material Science & Dye Chemistry: Potential use in the development of organic semiconductors, fluorescent dyes, and photoactive materials due to its conjugated aromatic system.
• Academic & Contract Research: Essential for fundamental research in heterocyclic chemistry and for contract research organizations (CROs) supporting client discovery projects.

Basic Information

Product Name	tert-Butyl 5-Amino-1H-benzo[de]isoquinoline-2(3H)-carboxylate
CAS No.	885272-11-7
Molecular Formula	C₁₇H₂₀N₂O₂
Molecular Weight	284.36 g/mol
Synonyms	5-Amino-1,2,3,4-tetrahydrobenzo[de]isoquinoline-2-carboxylic acid tert-butyl ester; 2-tert-Butoxycarbonyl-5-amino-1,2,3,4-tetrahydrobenzo[de]isoquinoline; 5-Amino-2-Boc-1,2,3,4-tetrahydrobenzo[de]isoquinoline; 5-Amino-THIQ-2-Boc; Boc-5-Amino-THIQ; tert-Butyl 5-amino-3,4-dihydro-1H-benzo[de]isoquinoline-2-carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Amino-1H-benzo[de]isoquinoline-2(3H)-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided to guarantee batch-to-batch consistency and support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.