Description

1-Cyclobutyl-6-Fluoro-3-Methyl-1H-Indazole is a high-purity, advanced pharmaceutical intermediate characterized by its unique indazole core functionalized with cyclobutyl and fluoro substituents. This compound is of significant value for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the discovery and development of new drug candidates.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of potential drug candidates, especially in oncology and central nervous system (CNS) therapeutic research.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis due to its modifiable indazole structure.
• API Development: Employed in the process development and scale-up stages for new chemical entities (NCEs) targeting specific biological pathways.
• Biochemical Tool Compound: Utilized in vitro and in vivo as a probe to study enzyme inhibition or receptor modulation in pharmacological assays.
• Contract Manufacturing: Supplied to CDMOs for custom synthesis projects under current Good Manufacturing Practice (cGMP) conditions for clinical trial material production.

Basic Information

Product Name	1-Cyclobutyl-6-Fluoro-3-Methyl-1H-Indazole
CAS No.	885271-99-8
Molecular Formula	C₁₂H₁₃FN₂
Molecular Weight	204.25 g/mol
Synonyms	1-Cyclobutyl-6-fluoro-3-methyl-1H-indazole; 6-Fluoro-3-methyl-1-cyclobutyl-1H-indazole; 1H-Indazole, 1-cyclobutyl-6-fluoro-3-methyl-; 885271-99-8; FC-1032; ZINC000103259535; AKOS005258065; BDBM50389365
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized and controlled using advanced analytical techniques, including HPLC, GC, NMR, and MS, to guarantee identity, purity, and consistency. We support development through commercial scale with appropriate quality documentation. Certificates of Analysis (COA) are available upon request, and custom purity grades (e.g., >98%, >99%) can be supplied to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0% (Standard Grade)
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.