Description

1-Cyclobutyl-3-Ethyl-6-Fluoro-1H-Indazole is a high-purity, advanced pharmaceutical intermediate with the CAS number 885271-96-5. This compound is a strategically designed indazole derivative, valued for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates, especially those targeting specific enzyme pathways.
• Oncology Research: Serves as a core scaffold for developing potential kinase inhibitors and other targeted cancer therapies.
• CNS Drug Discovery: Used in medicinal chemistry programs aimed at creating new treatments for neurological and psychiatric disorders.
• Chemical Biology: Employed as a molecular probe or tool compound to study biological processes and protein-ligand interactions.
• Process Development & Scale-up: Supplied for route scouting, optimization, and pilot-scale manufacturing of clinical trial materials.
• Custom Synthesis: A starting point for the custom synthesis of more complex, proprietary molecules for client-specific R&D projects.

Basic Information

Product Name	1-Cyclobutyl-3-Ethyl-6-Fluoro-1H-Indazole
CAS No.	885271-96-5
Molecular Formula	C₁₃H₁₅FN₂
Molecular Weight	218.27 g/mol
Synonyms	6-Fluoro-1-cyclobutyl-3-ethyl-1H-indazole; 1H-Indazole, 1-cyclobutyl-3-ethyl-6-fluoro-; 885271-96-5; 1-Cyclobutyl-3-ethyl-6-fluoroindazole; 6-Fluoro-3-ethyl-1-cyclobutylindazole; CBEFI (abbreviation); Cyclobutyl Ethyl Fluoro Indazole
EINECS	Contact for details

Quality Control

Our 1-Cyclobutyl-3-Ethyl-6-Fluoro-1H-Indazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.