Description

tert-Butyl 5-(Aminomethyl)Isoindoline-2-Carboxylate is a high-purity, protected isoindoline derivative featuring both a Boc-protected amine and a primary aminomethyl group, making it a versatile and critical chiral building block. This compound is essential for the synthesis of complex pharmaceutical intermediates, particularly in the development of active pharmaceutical ingredients (APIs) and bioactive molecules. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors for constructing constrained peptide mimetics and heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Peptidomimetic Chemistry: Used to construct conformationally restricted peptide analogs and protease inhibitors due to its rigid isoindoline core.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric synthesis and catalysis.
• Agrochemical Synthesis: Employed in the research and development of advanced, targeted agrochemicals.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring high-purity, complex heterocycles.

Basic Information

Product Name	tert-Butyl 5-(Aminomethyl)Isoindoline-2-Carboxylate
CAS No.	885271-40-9
Molecular Formula	C15H22N2O2
Molecular Weight	262.35 g/mol
Synonyms	5-(Aminomethyl)-2-isoindolinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 5-(aminomethyl)-2,3-dihydro-1H-isoindole-2-carboxylate; 2H-Isoindole-2-carboxylic acid, 5-(aminomethyl)-1,3-dihydro-, 1,1-dimethylethyl ester; Boc-5-(aminomethyl)isoindoline; 5-(Aminomethyl)isoindoline-2-carboxylic acid tert-butyl ester; 885271-40-9; tert-Butyl 5-(aminomethyl)isoindoline-2-carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-(Aminomethyl)Isoindoline-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.