Description

1-Boc-3-[1-(4-Fluoro-Benzyl)-1H-Benzoimidazol-2-Ylamino]-Piperidine is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound matters because it provides a critical, protected piperidine building block essential for medicinal chemistry research and the development of novel therapeutic agents. It is primarily needed by pharmaceutical R&D laboratories, contract research and manufacturing organizations (CROs/CMOs), and fine chemical suppliers focused on oncology, neurology, and other specialized drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, particularly those targeting protein kinases and other enzymes.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes to develop novel bioactive molecules.
• API Synthesis: Serves as a crucial building block in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs), especially in oncology and CNS therapeutic areas.
• Custom Synthesis & Scale-Up: Employed by CROs and CDMOs for custom synthesis projects, from milligram-scale research to kilogram-scale pilot production.
• Bioconjugation & Probe Development: Can be utilized in the development of chemical probes and bioconjugates for biochemical and diagnostic applications.

Basic Information

Product Name	1-Boc-3-[1-(4-Fluoro-Benzyl)-1H-Benzoimidazol-2-Ylamino]-Piperidine
CAS No.	885270-89-3
Molecular Formula	C25H31FN4O2
Molecular Weight	438.54 g/mol
Synonyms	1-Boc-3-{[1-(4-Fluorobenzyl)-1H-benzimidazol-2-yl]amino}piperidine; tert-Butyl 3-{[1-(4-fluorobenzyl)-1H-benzimidazol-2-yl]amino}piperidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-3-{[1-(4-fluorobenzyl)-1H-benzimidazol-2-yl]amino}piperidine; N-{1-[(4-Fluorophenyl)methyl]-1H-benzimidazol-2-yl}-1-(tert-butoxycarbonyl)piperidin-3-amine; 885270-89-3; 1-Boc-3-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-ylamino)piperidine
EINECS	Contact for details

Quality Control

Our 1-Boc-3-[1-(4-Fluoro-Benzyl)-1H-Benzoimidazol-2-Ylamino]-Piperidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.