Description

7'-Chloro-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline] is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic structure. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules targeting the central nervous system. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of innovative therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its spirocyclic and isoquinoline motifs.
• Chemical Reference Standard: Serves as an analytical standard for quality control and method development in API manufacturing.
• Organic Synthesis: Employed in academic and industrial research for constructing complex heterocyclic frameworks.
• Preclinical Development: Utilized in the scale-up synthesis of compounds for pharmacological and toxicological evaluation.

Basic Information

Product Name	7'-Chloro-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline]
CAS No.	885269-29-4
Molecular Formula	C12H12ClN
Molecular Weight	205.68 g/mol
Synonyms	7'-Chloro-1'H-spiro[cyclopropane-1,4'-isoquinoline]-2',3'-dihydro; 1'H-Spiro[cyclopropane-1,4'-isoquinoline], 7'-chloro-2',3'-dihydro-; 7-Chloro-2,3-dihydro-1H-spiro[cyclopropane-1,4-isoquinoline]; Spiro[cyclopropane-1,4'-isoquinoline], 7'-chloro-2',3'-dihydro-1'H-; CAS 885269-29-4
EINECS	Contact for details

Quality Control

Our 7'-Chloro-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline] is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.