Description

1H-Indole-6-Carboxylic Acid, 4-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-, Methyl Ester is a sophisticated, high-purity synthetic intermediate featuring a strategically protected hydroxyl group via a tert-butyldimethylsilyl (TBDMS) ether. This compound is critical for advanced organic synthesis, particularly in pharmaceutical research and development, where it serves as a key building block for constructing complex indole-based molecules. It is primarily utilized by medicinal chemists and process development scientists in the life sciences sector for the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new indole-derived bioactive compounds.
• Process Chemistry Development: Serves as a standardized intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions for clinical trial material production.
• Agrochemical Synthesis: Employed in the research and development of novel indole-based plant growth regulators or pesticides.
• Academic & Institutional Research: Utilized in universities and research institutes for methodological development in heterocyclic and organosilicon chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring protected indole scaffolds.

Basic Information

Item	Details
Product Name	1H-Indole-6-Carboxylic Acid, 4-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-, Methyl Ester
CAS No.	885266-75-1
Molecular Formula	C17H25NO3Si
Molecular Weight	319.48 g/mol
Synonyms	Methyl 4-((tert-butyldimethylsilyl)oxy)-1H-indole-6-carboxylate; 4-(tert-Butyldimethylsiloxy)-1H-indole-6-carboxylic Acid Methyl Ester; Methyl 4-(TBDMS-oxy)indole-6-carboxylate; 6-(Methoxycarbonyl)-1H-indol-4-yl tert-butyldimethylsilyl ether; 4-[(tert-Butyldimethylsilyl)oxy]-1H-indole-6-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 1H-Indole-6-Carboxylic Acid, 4-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-, Methyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.