Description

1-(2-tert-Butoxycarbonylamino-Ethyl)-1H-Indole-6-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a protected amine and a carboxylic acid functional group on an indole scaffold. This compound is critical for the synthesis of complex molecules, particularly in medicinal chemistry, where it serves as a versatile building block for constructing peptidomimetics and other bioactive compounds. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, including kinase inhibitors and GPCR-targeted drugs.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and CNS drug discovery programs.
• Peptidomimetic Synthesis: Used to incorporate indole-based structures into peptide backbones, creating analogs with enhanced metabolic stability and bioavailability.
• Medicinal Chemistry Research: Serves as a crucial scaffold for structure-activity relationship (SAR) studies and library synthesis in high-throughput screening.
• Bioconjugation & Probe Development: The carboxylic acid moiety allows for conjugation to other molecules, useful in creating fluorescent probes or targeted drug delivery systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials under GMP conditions.

Basic Information

Product Name	1-(2-tert-Butoxycarbonylamino-Ethyl)-1H-Indole-6-Carboxylic Acid
CAS No.	885266-68-2
Molecular Formula	C₁₆H₂₀N₂O₄
Molecular Weight	304.34 g/mol
Synonyms	1H-Indole-6-carboxylic acid, 1-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-; 1-[2-(tert-Butoxycarbonylamino)ethyl]-1H-indole-6-carboxylic acid; Boc-AEA(6-COOH)-OH; N-Boc-2-(6-carboxyindol-1-yl)ethylamine; 1-(2-((tert-Butoxycarbonyl)amino)ethyl)-1H-indole-6-carboxylic acid; 6-Carboxy-1-(2-N-Boc-aminoethyl)indole
EINECS	Contact for details

Quality Control

Our production of 1-(2-tert-Butoxycarbonylamino-Ethyl)-1H-Indole-6-Carboxylic Acid adheres to stringent quality management systems. Every batch is subjected to comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, which document all critical quality attributes. For advanced applications, we offer material produced under quality agreements suitable for cGMP (Current Good Manufacturing Practice) environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.