Description

3-(2-Carboxy-1-Methyl-Ethyl)-Indole-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a protected indole carboxylic acid moiety. This compound is critical for synthetic chemists requiring precise molecular building blocks for complex organic synthesis. It is primarily utilized in the research and development of novel active pharmaceutical ingredients (APIs), particularly within the fields of oncology and neurology.

Application

• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of complex drug candidates and novel active pharmaceutical ingredients (APIs).
• Protease Inhibitor Research: Used in the development of protease inhibitors, a crucial class of therapeutics for viral and metabolic diseases.
• Oncology Drug Discovery: Serves as a precursor in the synthesis of targeted cancer therapies and kinase inhibitors.
• Neurological Agent Synthesis: Employed in the research and development of compounds targeting neurological pathways and receptors.
• Peptidomimetic Chemistry: Integral for creating peptidomimetics, which are designed to mimic peptides for enhanced stability and bioavailability.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP guidelines.
• Academic & Industrial R&D: Used in research laboratories for methodological development and exploring new chemical entities.

Basic Information

Product Name	3-(2-Carboxy-1-Methyl-Ethyl)-Indole-1-Carboxylic Acid tert-Butyl Ester
CAS No.	885266-53-5
Molecular Formula	C17H21NO5
Molecular Weight	319.35 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-3-(2-carboxy-1-methylethyl)indole; 1-Boc-3-(2-carboxypropyl)indole; tert-Butyl 3-(2-carboxy-1-methylethyl)-1H-indole-1-carboxylate; 3-(2-Carboxypropyl)-1H-indole-1-carboxylic acid tert-butyl ester; 1-Boc-3-(2-carboxy-1-methylethyl)-1H-indole; Indole-1-carboxylic acid, 3-(2-carboxy-1-methylethyl)-, 1,1-dimethylethyl ester; BOC-Protected Indole-3-propionic Acid Derivative
EINECS	Contact for details

Quality Control

Our 3-(2-Carboxy-1-Methyl-Ethyl)-Indole-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Production can be aligned with cGMP standards for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.