Description

2-Amino-4-(4-Fluorophenyl)-5-Methylthiophene-3-Carbonitrile is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its molecular architecture, featuring a fluorinated phenyl ring and a nitrile group on a thiophene scaffold, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly for kinase inhibitors, anti-inflammatory agents, and central nervous system (CNS) active compounds.
• Agrochemical Research: Serves as a core structure for developing new herbicides, fungicides, and insecticides, leveraging the bioactivity of the thiophene and fluorophenyl motifs.
• Material Science: Used in the development of organic semiconductors, conductive polymers, and advanced dyes due to its electron-rich thiophene core and functional handles for polymerization.
• Chemical Biology Probe Development: Employed as a scaffold for creating molecular probes and tags to study biological processes and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring specialized fluorinated heterocycles.

Basic Information

Product Name	2-Amino-4-(4-Fluorophenyl)-5-Methylthiophene-3-Carbonitrile
CAS No.	884497-33-0
Molecular Formula	C12H9FN2S
Molecular Weight	232.28 g/mol
Synonyms	2-Amino-4-(4-fluorophenyl)-5-methylthiophene-3-carbonitrile; 5-Methyl-2-amino-4-(4-fluorophenyl)thiophene-3-carbonitrile; 4-(4-Fluorophenyl)-2-amino-5-methylthiophene-3-carbonitrile; 884497-33-0; Thiophene-3-carbonitrile, 2-amino-4-(4-fluorophenyl)-5-methyl-; AKOS BRN 0971
EINECS	Contact for details

Quality Control

Every batch of 2-Amino-4-(4-Fluorophenyl)-5-Methylthiophene-3-Carbonitrile is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.