Description

4,5,6-Trifluoro-1H-Indole-2-Carboxylic Acid is a high-value fluorinated indole derivative, a crucial advanced intermediate in modern synthetic chemistry. Its trifluoromethylated indole core offers unique electronic and steric properties, making it indispensable for constructing complex molecules with enhanced biological activity and metabolic stability. This compound is primarily sought after by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients, including kinase inhibitors and other targeted therapeutics.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and fungicides, leveraging the fluorine atoms for improved efficacy and environmental profile.
• Material Science Precursor: Serves as a monomer or precursor for specialty polymers and organic electronic materials requiring fluorinated aromatic systems.
• Chemical Biology Probe Development: Employed in the design and synthesis of molecular probes and labeled compounds for biochemical and diagnostic research.
• Academic & Contract Research: Utilized in university and CRO laboratories for methodological studies in fluorination chemistry and heterocyclic compound synthesis.

Basic Information

Product Name	4,5,6-Trifluoro-1H-Indole-2-Carboxylic Acid
CAS No.	884494-64-8
Molecular Formula	C9H4F3NO2
Molecular Weight	215.13 g/mol
Synonyms	4,5,6-Trifluoroindole-2-carboxylic acid; 2-Carboxy-4,5,6-trifluoroindole; 1H-Indole-2-carboxylic acid, 4,5,6-trifluoro-; 4,5,6-Trifluoro-1H-indole-2-carboxylic acid; 884494-64-8; 4,5,6-Trifluoroindole-2-carboxylate
EINECS	Contact for details

Quality Control

Our 4,5,6-Trifluoro-1H-Indole-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and away from moisture and direct light to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.