Description

4,5-Difluoro-1H-Indole-2-Carboxylic Acid is a high-value fluorinated indole derivative that serves as a critical building block in advanced organic synthesis. Its core value lies in the strategic placement of fluorine atoms, which are essential for modulating the biological activity, metabolic stability, and physicochemical properties of target molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, particularly in oncology, CNS disorders, and anti-inflammatory therapies.
• Agrochemical Research: Used to develop novel herbicides, fungicides, and insecticides where the difluoroindole scaffold contributes to enhanced efficacy and environmental profile.
• Material Science: Serves as a monomer or functional additive in the creation of specialty polymers and organic electronic materials.
• Chemical Biology: Employed as a probe or labeling reagent in biochemical assays and diagnostic development due to its fluorinated structure.
• Academic & Contract Research: Utilized in methodological development and discovery chemistry within university and CRO laboratories.

Basic Information

Product Name	4,5-Difluoro-1H-Indole-2-Carboxylic Acid
CAS No.	884494-61-5
Molecular Formula	C9H5F2NO2
Molecular Weight	197.14 g/mol
Synonyms	4,5-Difluoroindole-2-carboxylic acid; 2-Carboxy-4,5-difluoroindole; 1H-Indole-2-carboxylic acid, 4,5-difluoro-; 4,5-Difluoro-1H-indole-2-carboxylic acid; 884494-61-5; 4,5-Difluoroindole-2-carboxylate
EINECS	Contact for details

Quality Control

Our 4,5-Difluoro-1H-Indole-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is light-sensitive (store away from light) and should be handled with appropriate precautions for materials soluble in strong acid/organic solvent. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.