Description

(5Z)-5-[(5-Bromothiophen-2-Yl)Methylidene]-2-[4-(2-Hydroxyethyl)Piperazin-1-Yl]-1,3-Thiazol-4(5H)-One is a high-purity, advanced pharmaceutical intermediate and research chemical characterized by its unique heterocyclic structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel therapeutic agents targeting a range of biological pathways. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions engaged in drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization to develop new chemical entities with improved efficacy and pharmacokinetic profiles.
• Biochemical Tool Compound: Acts as a selective probe or inhibitor in enzymatic assays and receptor binding studies to elucidate biological mechanisms and validate new drug targets.
• Organic Synthesis: Employed in advanced organic synthesis for constructing complex heterocyclic frameworks containing thiophene, thiazolone, and piperazine moieties.
• Academic & Institutional R&D: Utilized in university and government research laboratories for fundamental studies in organic chemistry and pharmacology.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting the pharmaceutical industry with custom synthesis and process development.

Basic Information

Product Name	(5Z)-5-[(5-Bromothiophen-2-Yl)Methylidene]-2-[4-(2-Hydroxyethyl)Piperazin-1-Yl]-1,3-Thiazol-4(5H)-One
CAS No.	884435-81-8
Molecular Formula	C14H16BrN3O2S2
Molecular Weight	402.33 g/mol
Synonyms	5-[(5-Bromo-2-thienyl)methylene]-2-[4-(2-hydroxyethyl)-1-piperazinyl]-4(5H)-thiazolone; 2-[4-(2-Hydroxyethyl)piperazin-1-yl]-5-[(5-bromothiophen-2-yl)methylidene]-1,3-thiazol-4(5H)-one; (5Z)-5-[(5-Bromothien-2-yl)methylene]-2-[4-(2-hydroxyethyl)piperazin-1-yl]-1,3-thiazol-4(5H)-one; CAS 884435-81-8; Thiazolone derivative, bromothiophene piperazine; 5-[(5-Bromothiophen-2-yl)methylene]-2-[4-(2-hydroxyethyl)piperazin-1-yl]-4H-thiazol-4-one
EINECS	Contact for details

Quality Control

Our (5Z)-5-[(5-Bromothiophen-2-Yl)Methylidene]-2-[4-(2-Hydroxyethyl)Piperazin-1-Yl]-1,3-Thiazol-4(5H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.