Description

7-Chloro-4-(Trifluoromethyl)-1H-Indole-2-Carboxylic Acid is a high-value, multi-functional indole derivative that serves as a critical building block in advanced organic synthesis. Its unique halogenated and trifluoromethylated structure makes it an essential intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating compounds with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in oncology, CNS disorders, and anti-infective therapies.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the indole core and fluorine atoms contribute to efficacy and environmental profile.
• Material Science Research: Serves as a precursor for functionalized organic materials, including ligands for catalysis and monomers for specialty polymers.
• Biochemical Tool Compound: Employed in academic and industrial research as a scaffold for probing biological pathways and enzyme inhibition.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	7-Chloro-4-(Trifluoromethyl)-1H-Indole-2-Carboxylic Acid
CAS No.	883523-01-1
Molecular Formula	C10H5ClF3NO2
Molecular Weight	263.60 g/mol
Synonyms	7-Chloro-4-(trifluoromethyl)-1H-indole-2-carboxylic acid; 1H-Indole-2-carboxylic acid, 7-chloro-4-(trifluoromethyl)-; 883523-01-1; 7-Chloro-4-trifluoromethylindole-2-carboxylic acid; 4-(Trifluoromethyl)-7-chloro-1H-indole-2-carboxylic acid; 7-Chloro-4-(trifluoromethyl)indole-2-carboxylic acid; 2-Carboxy-7-chloro-4-(trifluoromethyl)indole
EINECS	Contact for details

Quality Control

Every batch of 7-Chloro-4-(Trifluoromethyl)-1H-Indole-2-Carboxylic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure consistency and traceability for your regulatory filings. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by HPLC, NMR, and MS. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.