Description

(E)-2-(3-Fluoro-4-Morpholinobenzoyl)-3-(1H-Indol-3-Yl)-2-Propenenitrile is a high-purity, advanced pharmaceutical intermediate designed for research and development in modern drug discovery. This compound is critical for medicinal chemists developing targeted therapies, particularly in oncology and other disease areas involving kinase inhibition. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers requiring a reliable supply of complex, high-value building blocks.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small-molecule drug candidates, particularly kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new therapeutic agents.
• Biochemical Assay Development: Serves as a reference standard or probe compound in high-throughput screening (HTS) and enzymatic assays.
• Academic Research: Employed in university and institutional labs for investigating new chemical entities and their biological pathways.
• Preclinical Development: Used in the synthesis of compounds for pharmacokinetic, pharmacodynamic, and toxicology studies.

Basic Information

Product Name	(E)-2-(3-Fluoro-4-Morpholinobenzoyl)-3-(1H-Indol-3-Yl)-2-Propenenitrile
CAS No.	882747-29-7
Molecular Formula	C22H18FN3O2
Molecular Weight	375.40 g/mol
Synonyms	(E)-2-(3-Fluoro-4-morpholinobenzoyl)-3-(1H-indol-3-yl)acrylonitrile; 2-[(E)-2-Cyano-2-(1H-indol-3-yl)ethenyl]-3-fluoro-4-morpholinobenzoic Acid; 882747-29-7; (E)-3-(1H-Indol-3-yl)-2-(3-fluoro-4-morpholinobenzoyl)acrylonitrile; 3-Fluoro-4-morpholinobenzoic acid (E)-2-cyano-2-(1H-indol-3-yl)vinyl ester; Acrylonitrile, 2-(3-fluoro-4-morpholinobenzoyl)-3-(1H-indol-3-yl)-, (E)-
EINECS	Contact for details

Quality Control

Our (E)-2-(3-Fluoro-4-Morpholinobenzoyl)-3-(1H-Indol-3-Yl)-2-Propenenitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. All materials are characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.