Description

2-Amino-6-Trifluoromethyl-1H-Indole-3-Carboxylic Acid Methyl Ester is a high-purity, synthetically versatile indole derivative that serves as a critical building block in advanced organic synthesis. Its molecular structure, featuring both an amino group and a trifluoromethyl substituent, makes it a valuable precursor for creating novel compounds with enhanced biological activity and physicochemical properties. This intermediate is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel drug candidates, particularly in oncology, neurology, and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the trifluoromethyl group can improve metabolic stability and bioavailability.
• Material Science Research: Serves as a precursor for functional dyes, organic semiconductors, and other specialty chemicals requiring complex heterocyclic cores.
• Chemical Biology & Proteomics: Employed as a scaffold or labeling agent in the design of molecular probes and enzyme inhibitors for biochemical research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in bespoke synthesis projects and scale-up campaigns.

Basic Information

Product Name	2-Amino-6-Trifluoromethyl-1H-Indole-3-Carboxylic Acid Methyl Ester
CAS No.	882309-72-0
Molecular Formula	C11H9F3N2O2
Molecular Weight	258.20 g/mol
Synonyms	Methyl 2-Amino-6-(trifluoromethyl)-1H-indole-3-carboxylate; 2-Amino-6-trifluoromethylindole-3-carboxylic acid methyl ester; 6-(Trifluoromethyl)-1H-indole-3-carboxylic acid, 2-amino-, methyl ester; 1H-Indole-3-carboxylic acid, 2-amino-6-(trifluoromethyl)-, methyl ester
EINECS	Contact for details

Quality Control

Every batch of 2-Amino-6-Trifluoromethyl-1H-Indole-3-Carboxylic Acid Methyl Ester is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard grade typically meets a purity specification of ≥97% (HPLC), with detailed impurity profiling available. A Certificate of Analysis (COA) documenting all test results is provided with each shipment, and we support customer audits and regulatory submissions as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.