Description

2-Thiophenesulfonamide, n-[3-(Trifluoromethyl)Phenyl]-5-[[4-(Trifluoromethyl)-2-Pyridinyl]Sulfonyl]- is a high-purity, advanced pharmaceutical intermediate featuring a complex sulfonamide structure with multiple trifluoromethyl groups. This compound matters for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting specific enzyme pathways. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, especially within the fields of oncology and metabolic disease research.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of novel drug candidates, particularly kinase inhibitors.
• Biochemical Research: Used as a reference standard or probe molecule in enzymatic assays and target validation studies.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for client projects.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and drug discovery methodologies.

Basic Information

Product Name	2-Thiophenesulfonamide, n-[3-(Trifluoromethyl)Phenyl]-5-[[4-(Trifluoromethyl)-2-Pyridinyl]Sulfonyl]-
CAS No.	882292-76-4
Molecular Formula	C17H10F6N2O2S2
Molecular Weight	460.39 g/mol
Synonyms	N-[3-(Trifluoromethyl)phenyl]-5-[[4-(trifluoromethyl)pyridin-2-yl]sulfonyl]thiophene-2-sulfonamide; 5-[(4-Trifluoromethylpyridin-2-yl)sulfonyl]-N-[3-(trifluoromethyl)phenyl]thiophene-2-sulfonamide; 882292-76-4; Thiophene-2-sulfonamide derivative; Sulfonamide kinase intermediate
EINECS	Contact for details

Quality Control

Our 2-Thiophenesulfonamide derivative is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the exacting standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the original container sealed under inert atmosphere when not in use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.