Description

tert-Butyl(S)-(1-Hydroxy-3-(1-Methyl-1H-Indol-3-Yl)Propan-2-Yl)Carbamate is a high-purity chiral building block and advanced pharmaceutical intermediate of significant commercial importance. Its value lies in its role as a key synthon for the synthesis of complex bioactive molecules, particularly in the development of new therapeutic agents. This compound is essential for research institutions and pharmaceutical manufacturers focused on innovative drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Peptidomimetic Synthesis: Used in the construction of peptide-like molecules (peptidomimetics) for drug development, leveraging its protected amine and hydroxyl functionalities.
• Asymmetric Synthesis: Serves as a versatile starting material for the preparation of enantiomerically pure compounds in medicinal chemistry research.
• API Development: Employed in the research and scale-up phases of Active Pharmaceutical Ingredient (API) manufacturing for clinical trials and commercial production.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	tert-Butyl(S)-(1-Hydroxy-3-(1-Methyl-1H-Indol-3-Yl)Propan-2-Yl)Carbamate
CAS No.	882169-75-7
Molecular Formula	C₁₇H₂₄N₂O₃
Molecular Weight	304.39 g/mol
Synonyms	(S)-tert-Butyl (1-hydroxy-3-(1-methyl-1H-indol-3-yl)propan-2-yl)carbamate; (S)-N-Boc-1-(1-Methyl-1H-indol-3-yl)-3-amino-2-propanol; Boc-L-Tryptophanol; (2S)-3-(1-Methyl-1H-indol-3-yl)-2-[(tert-butoxycarbonyl)amino]-1-propanol; (S)-2-((tert-Butoxycarbonyl)amino)-3-(1-methyl-1H-indol-3-yl)propan-1-ol; BOC-DL-Tryptophanol; tert-Butyl N-[(1S)-1-(hydroxymethyl)-2-(1-methylindol-3-yl)ethyl]carbamate
EINECS	Contact for details

Quality Control

Our production of tert-Butyl(S)-(1-Hydroxy-3-(1-Methyl-1H-Indol-3-Yl)Propan-2-Yl)Carbamate adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the exacting standards required for pharmaceutical R&D and cGMP manufacturing. Certificates of Analysis (COA) with detailed chromatographic data are provided for full traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.