Description

3-(6,7-Dimethoxy-3,4-Dihydro-1H-Isoquinolin-2-Yl)-Propionic Acid Hydrochloride is a high-purity, advanced pharmaceutical intermediate and research chemical. This compound is critical for the synthesis of complex molecules, offering a versatile building block for medicinal chemistry and drug discovery programs. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of active pharmaceutical ingredients (APIs) requiring precise and reliable synthetic pathways.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of tetrahydroisoquinoline-based active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Serves as a versatile building block for constructing complex molecular libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Neurological & Cardiovascular Research: Used in the development of compounds targeting receptors and enzymes relevant to central nervous system and cardiovascular diseases.
• Alkaloid Synthesis: Integral to the synthetic pathways for creating isoquinoline alkaloids and their analogs for biological evaluation.
• Process Chemistry & Scale-Up: Employed in process development and optimization for the commercial-scale manufacturing of specialty fine chemicals.
• Academic Research: Utilized in university and institutional laboratories for organic synthesis projects and methodological development.

Basic Information

Product Name	3-(6,7-Dimethoxy-3,4-Dihydro-1H-Isoquinolin-2-Yl)-Propionic Acid Hydrochloride
CAS No.	881686-34-6
Molecular Formula	C₁₄H₂₀ClNO₄
Molecular Weight	301.77 g/mol
Synonyms	3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)propanoic acid hydrochloride; 2-(3-Carboxypropyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride; 6,7-Dimethoxy-2-(3-carboxypropyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride; 3-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)propanoic acid hydrochloride; Tetrahydroisoquinoline propionic acid derivative HCl
EINECS	Contact for details

Quality Control

Our 3-(6,7-Dimethoxy-3,4-Dihydro-1H-Isoquinolin-2-Yl)-Propionic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.