Description

1-(Benzenesulfonyl)-3-Bromo-1H-Pyrrolo[2,3-B]Pyridine is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused heterocyclic structure. This compound is of significant commercial value for its role as a key building block in the synthesis of complex bioactive molecules, particularly kinase inhibitors. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, including potential treatments for oncology and inflammatory diseases.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of targeted small-molecule drugs, especially protein kinase inhibitors.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with improved efficacy and selectivity.
• Organic Synthesis Building Block: Serves as a versatile scaffold for further functionalization via cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) due to the reactive bromo substituent.
• Biochemical Tool Compound: Employed in biochemical assays to study enzyme function and for the discovery of novel biological pathways.
• Contract Development and Manufacturing (CDMO): Supplied to CDMOs for the cGMP production of active pharmaceutical ingredients (APIs) for clinical trials and commercial supply.

Basic Information

Product Name	1-(Benzenesulfonyl)-3-Bromo-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	880769-95-9
Molecular Formula	C₁₅H₁₁BrN₂O₂S
Molecular Weight	363.23 g/mol
Synonyms	3-Bromo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 3-Bromo-1H-pyrrolo[2,3-b]pyridine 1-(benzenesulfonate); 1-Benzenesulfonyl-3-bromo-1H-pyrrolo[2,3-b]pyridine; 3-Bromo-1-(benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 3-bromo-1-[(phenylsulfonyl)]-; 880769-95-9
EINECS	Contact for details

Quality Control

Our production of 1-(Benzenesulfonyl)-3-Bromo-1H-Pyrrolo[2,3-B]Pyridine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is fully characterized and tested against rigorous in-house specifications, which typically include identity confirmation by spectroscopic methods (NMR, IR, MS), purity assessment by HPLC, and control of specific impurities. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound should be kept under an inert atmosphere for long-term storage to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.