Description

1-Boc-5-Formylindoline is a high-purity, advanced pharmaceutical intermediate and versatile building block in organic synthesis. Its value lies in the strategic combination of a protected amine (Boc) and a reactive aldehyde (formyl) group, enabling precise and efficient construction of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates, especially those containing indoline or related heterocyclic scaffolds.
• Organic Synthesis Building Block: Utilized in multi-step synthesis for the introduction of formyl and protected amine functionalities via reactions like reductive amination or nucleophilic addition.
• Agrochemical Research: Serves as a starting material for developing new pesticides and herbicides with enhanced efficacy.
• Material Science: Potential monomer or precursor for specialty polymers and functional materials.
• Academic & R&D: Used in medicinal chemistry research for library synthesis and structure-activity relationship (SAR) studies.
• Peptide Mimetics: Employed in the design and synthesis of peptidomimetics and constrained analogs.

Basic Information

Product Name	1-Boc-5-Formylindoline
CAS No.	879887-32-8
Molecular Formula	C14H17NO3
Molecular Weight	247.29 g/mol
Synonyms	tert-Butyl 5-formyl-2,3-dihydro-1H-indole-1-carboxylate; 5-Formylindoline-1-carboxylic acid tert-butyl ester; 1-N-Boc-5-formylindoline; N-Boc-5-formylindoline; 1-(tert-Butoxycarbonyl)-5-formylindoline; 5-Formyl-1H-indoline-1-carboxylic acid, 1,1-dimethylethyl ester; 879887-32-8
EINECS	Contact for details

Quality Control

Our 1-Boc-5-Formylindoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.