Description

1-Cyclopropanecarbonyl-2,3-dihydro-1H-indole-5-sulfonyl chloride is a high-purity, advanced pharmaceutical intermediate characterized by its reactive sulfonyl chloride group. This compound is critical for medicinal chemists as a key building block in the synthesis of novel bioactive molecules, particularly in the development of protease inhibitors and other targeted therapies. It is primarily sought after by R&D laboratories and production facilities in the pharmaceutical and biotechnology sectors for constructing complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in protease inhibitor research.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Bioconjugation & Probe Development: The reactive sulfonyl chloride moiety enables labeling and conjugation with amines and hydroxyl groups for creating biochemical probes.
• Chemical Library Synthesis: Employed in combinatorial chemistry and high-throughput screening to generate diverse compound libraries for biological evaluation.
• Agrochemical Research: Serves as a precursor in the development of new active ingredients with potential herbicidal or insecticidal properties.
• Material Science: Investigated as a monomer or cross-linking agent for creating specialized polymers with unique properties.

Basic Information

Item	Detail
Product Name	1-Cyclopropanecarbonyl-2,3-dihydro-1H-indole-5-sulfonyl chloride
CAS No.	879562-21-7
Molecular Formula	C12H12ClNO3S
Molecular Weight	285.75 g/mol
Synonyms	5-(Chlorosulfonyl)-1-(cyclopropanecarbonyl)-2,3-dihydro-1H-indole; 1H-Indole-5-sulfonyl chloride, 1-(cyclopropylcarbonyl)-2,3-dihydro-; 1-(Cyclopropanecarbonyl)-2,3-dihydroindole-5-sulfonyl chloride; 1-Cyclopropanecarbonyl-2,3-dihydroindole-5-sulfonyl chloride; 1-Cyclopropanecarbonyl-2,3-dihydro-1H-indole-5-sulfonyl chloride; 879562-21-7; 5-Sulfonyl chloride derivative of 1-cyclopropanecarbonyl-2,3-dihydro-1H-indole
EINECS	Contact for details

Quality Control

Our 1-Cyclopropanecarbonyl-2,3-dihydro-1H-indole-5-sulfonyl chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.