Description

1-((2-(Trimethylsilyl)Ethoxy)Methyl)-1H-Pyrrolo[2,3-B]Pyridine CAS NO 879132-46-4 is a high-purity, advanced pharmaceutical intermediate featuring a versatile pyrrolopyridine core protected by a (2-(trimethylsilyl)ethoxy)methyl (SEM) group. This compound is critical for enabling complex synthetic routes in medicinal chemistry, particularly for the development of kinase inhibitors and other targeted therapeutics. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of complex drug molecules, especially kinase inhibitors.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for new therapeutic agents.
• Process Chemistry Development: Serves as a critical starting material or intermediate in scaling up API manufacturing processes.
• Organic Synthesis: The SEM-protected nitrogen allows for selective reactions on other parts of the heterocyclic scaffold.
• Bioconjugation & Probe Development: Potential use in creating labeled compounds for biochemical and diagnostic assays.

Basic Information

Item	Details
Product Name	1-((2-(Trimethylsilyl)Ethoxy)Methyl)-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	879132-46-4
Molecular Formula	C14H22N2OSi
Molecular Weight	262.42 g/mol
Synonyms	1-((2-(Trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 1-[[2-(trimethylsilyl)ethoxy]methyl]-; 1-SEM-7-azaindole; 1-((2-(Trimethylsilyl)Ethoxy)Methyl)-7-azaindole; 1-SEM-1H-pyrrolo[2,3-b]pyridine; SEM-7-Azaindole; 879132-46-4; Azaindole SEM-protected derivative
EINECS	Contact for details

Quality Control

Our 1-((2-(Trimethylsilyl)Ethoxy)Methyl)-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP standards where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.