Description

2-Boc-1,2,3,4-Tetrahydroisoquinoline-8-Carboxylic Acid is a high-purity, protected amino acid derivative that serves as a critical building block in advanced organic synthesis. Its primary value lies in providing a versatile and reactive scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on novel drug candidates, especially within the fields of central nervous system (CNS) therapeutics and protease inhibitors.

Application

• Pharmaceutical Intermediate: Key synthetic precursor for the development of novel active pharmaceutical ingredients (APIs), particularly in neurological and cardiovascular drug discovery programs.
• Peptidomimetics Research: Used as a constrained, non-natural amino acid analog to design and synthesize peptide-like molecules with enhanced metabolic stability and bioavailability.
• Combinatorial Chemistry: A valuable building block in solid-phase and solution-phase parallel synthesis for creating diverse chemical libraries for high-throughput screening.
• Protease Inhibitor Development: The tetrahydroisoquinoline core is a privileged structure in the design of inhibitors for various enzymes, including kinases and proteases.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and molecular probes for studying biological pathways and target engagement.
• Scale-up Process Chemistry: Serves as a starting material for the optimization and kilogram-scale production of candidate drugs during clinical development phases.

Basic Information

Product Name	2-Boc-1,2,3,4-Tetrahydroisoquinoline-8-Carboxylic Acid
CAS No.	878798-87-9
Molecular Formula	C15H19NO4
Molecular Weight	277.32 g/mol
Synonyms	8-Carboxy-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid 1,1-dimethylethyl ester; 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-8-carboxylic acid; 2-Boc-Tic-OH; Boc-Tic-OH; 2-N-Boc-1,2,3,4-tetrahydroisoquinoline-8-carboxylic acid; (2-Boc-1,2,3,4-tetrahydro-8-isoquinolyl)carboxylic acid; 2-(tert-Butyloxycarbonylamino)-3,4-dihydro-1H-isoquinoline-8-carboxylic acid
EINECS	Contact for details

Quality Control

Every batch of 2-Boc-1,2,3,4-Tetrahydroisoquinoline-8-Carboxylic Acid is manufactured under strict quality management systems. We employ advanced analytical techniques, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.