Description

(5-(2-Amino-5-Methylthiazol-4-Yl)Indolin-1-Yl)(o-Tolyl)Methanone CAS NO 878704-24-6 is a high-purity, advanced pharmaceutical intermediate featuring a complex heterocyclic structure. This compound is of significant value for research and development in medicinal chemistry, particularly in the synthesis of novel therapeutic agents. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers focused on developing new drug candidates.

Application

This specialized intermediate serves as a critical building block in several advanced chemical synthesis pathways.

• Pharmaceutical Intermediate: Key precursor in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) or oncology targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel drug discovery programs.
• Chemical Biology Probe Synthesis: Employed in the creation of molecular probes for studying biological pathways and target validation.
• Custom Synthesis: Serves as a starting material for contract manufacturing organizations (CMOs) producing bespoke compounds for client research.
• Heterocyclic Compound Library Development: A valuable component for constructing diverse screening libraries focused on thiazole and indoline chemotypes.

Basic Information

Product Name	(5-(2-Amino-5-Methylthiazol-4-Yl)Indolin-1-Yl)(o-Tolyl)Methanone
CAS No.	878704-24-6
Molecular Formula	C20H19N3OS
Molecular Weight	349.45 g/mol
Synonyms	1-(2-Methylbenzoyl)-5-(2-amino-5-methyl-4-thiazolyl)indoline; (5-(2-Amino-5-methylthiazol-4-yl)-2,3-dihydro-1H-indol-1-yl)(2-methylphenyl)methanone; o-Tolyl[5-(2-amino-5-methyl-4-thiazolyl)-1-indolinyl]methanone; 878704-24-6; Methanone, (5-(2-amino-5-methyl-4-thiazolyl)-2,3-dihydro-1H-indol-1-yl)-2-methylphenyl-; AKOS025311317; AT14884; SCHEMBL15506211
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material with a typical purity of ≥97% (by HPLC), suitable for advanced research applications. Every batch is supported by comprehensive analytical data, including HPLC chromatograms and NMR spectra. Certificates of Analysis (COA) are available upon request, detailing identity, purity, and impurity profiles to meet the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light). For long-term storage, consider storing under an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Related Substances (HPLC)	Total impurities ≤3.0%
Single Unknown Impurity	≤1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.