Description

1-(3-Chloro-4-Fluorophenyl)Ethan-1-Ol is a versatile chiral alcohol intermediate featuring both chloro and fluoro substituents on the aromatic ring. This molecular architecture is critical for imparting specific electronic and steric properties, making it a valuable building block in advanced synthesis. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical sectors for the creation of novel active compounds.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-inflammatory drugs.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides, where the halogenated phenyl group enhances biological activity.
• Liquid Crystal Materials: Serves as a core component in the production of fluorinated liquid crystals for display technologies.
• Organic Electronic Materials: Acts as a building block for charge-transport materials and semiconductors in OLEDs and OFETs.
• Asymmetric Catalysis: Employed as a ligand precursor or a chiral pool reagent in stereoselective synthesis.
• Custom Synthesis & Contract Research: A high-value starting material for fine chemical manufacturers and CROs/CMOs developing proprietary compounds.

Basic Information

Product Name	1-(3-Chloro-4-Fluorophenyl)Ethan-1-Ol
CAS No.	878572-03-3
Molecular Formula	C8H8ClFO
Molecular Weight	174.60 g/mol
Synonyms	1-(3-Chloro-4-fluorophenyl)ethanol; α-Methyl-3-chloro-4-fluorobenzyl alcohol; 3-Chloro-4-fluoro-α-methylbenzenemethanol; (3-Chloro-4-fluorophenyl)methylcarbinol; 1-(3-Chloro-4-fluorophenyl)ethyl alcohol; 2-(3-Chloro-4-fluorophenyl)propan-2-ol (isomeric check); 878572-03-3; FC6H3(Cl)CH(OH)CH3
EINECS	Contact for details

Quality Control

Our production of 1-(3-Chloro-4-Fluorophenyl)Ethan-1-Ol adheres to stringent quality management protocols. Every batch is analyzed using advanced techniques like HPLC, GC, and NMR to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality system is designed to support cGMP and ISO standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after use to prevent moisture absorption, which may affect stability and performance. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.