Description

(S)-(+)-3,3'-Bis(3,5-Bis(Trifluoromethyl)Phenyl)-1,1'-Binaphthyl-2,2'-Diyl Hydrogenphosphate, 95% is a high-purity, chiral binaphthyl-based organocatalyst and ligand. This compound is valued for its exceptional enantioselectivity and stability, making it a critical component in advanced asymmetric synthesis. It is primarily sought by research and development teams in the pharmaceutical and fine chemical industries for creating high-value chiral intermediates and active pharmaceutical ingredients (APIs).

Application

• Asymmetric Catalysis: Serves as a highly effective chiral Brønsted acid catalyst for enantioselective reactions, including Mannich, Friedel-Crafts, and transfer hydrogenation reactions.
• Pharmaceutical Intermediate Synthesis: Used in the research and production of chiral drug candidates, particularly for central nervous system (CNS) and cardiovascular targets.
• Ligand for Metal Complexes: Functions as a privileged chiral ligand for transition metal catalysts, enhancing stereocontrol in cross-coupling and hydrogenation processes.
• Fine Chemical Manufacturing: Enables the synthesis of enantiomerically pure flavors, fragrances, and agrochemical intermediates.
• Methodology Development: A key reagent in academic and industrial laboratories for developing new asymmetric synthetic protocols.
• Material Science Research: Investigated for use in chiral dopants for liquid crystals and other advanced optical materials.

Basic Information

Product Name	(S)-(+)-3,3'-Bis(3,5-Bis(Trifluoromethyl)Phenyl)-1,1'-Binaphthyl-2,2'-Diyl Hydrogenphosphate, 95%
CAS No.	878111-17-2
Molecular Formula	C46H22F12O4P
Molecular Weight	906.62 g/mol
Synonyms	(S)-TRIP; (S)-3,3'-Bis(3,5-bis(trifluoromethyl)phenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; (S)-BINOL-derived phosphoric acid; Chiral phosphoric acid catalyst TRIP; (S)-Phosphoric acid tris(3,5-bis(trifluoromethyl)phenyl)binaphthyl ester; (S)-H8-BINOL phosphoric acid derivative; Asymmetric Brønsted acid catalyst; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our (S)-(+)-3,3'-Bis(3,5-Bis(Trifluoromethyl)Phenyl)-1,1'-Binaphthyl-2,2'-Diyl Hydrogenphosphate, 95% is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the specifications required for sensitive asymmetric synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.