Description

2-((Benzyloxy)Carbonyl)-1,2,3,4-Tetrahydroisoquinoline-7-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate (API intermediate) of significant importance in modern organic synthesis. This compound serves as a critical building block for the development of novel therapeutic agents, particularly in the fields of neurology and oncology. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of complex heterocyclic compounds and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key precursor in the multi-step synthesis of potent drug candidates targeting central nervous system (CNS) disorders.
• Protease Inhibitor Research: Used in the development and screening of novel protease inhibitors due to its tetrahydroisoquinoline scaffold.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Peptidomimetic Synthesis: Employed in the construction of peptidomimetics, which are molecules that mimic the structure and function of peptides.
• Chemical Biology Probes: Utilized for the synthesis of labeled compounds and probes to study biological pathways and enzyme functions.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke synthesis for client projects.

Basic Information

Product Name	2-((Benzyloxy)Carbonyl)-1,2,3,4-Tetrahydroisoquinoline-7-Carboxylic Acid
CAS No.	877861-35-3
Molecular Formula	C18H17NO4
Molecular Weight	311.33 g/mol
Synonyms	7-Carboxy-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid benzyl ester; 1,2,3,4-Tetrahydro-7-isoquinolinecarboxylic acid, 2-[(phenylmethoxy)carbonyl]-; 2-(Benzyloxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid; 2-[(Benzyloxy)carbonyl]-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid; 2-Cbz-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid; 2-Cbz-Tic-OH; 2-Cbz-7-carboxy-1,2,3,4-tetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our 2-((Benzyloxy)Carbonyl)-1,2,3,4-Tetrahydroisoquinoline-7-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for each lot, supporting its use in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed when not in use to prevent exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.